DNA Methylation and gene expression patterns are widely altered in fetal growth restriction and associated with FGR development

Fetal growth restriction (FGR) is the failure of fetus toachieve its genetically determined potential, which increasesrisks for a variety genetic diseases, such as type 2 diabetes mellitus, coronary artery disease, and stroke, during lifetime. The dysregulation DNA methylationis known to interact with environmental fluctuations, affect gene expressions comprehensively, be fatal development in specific cases. Therefore, we set out find epigenetic transcriptomic alterations associated FGR development. We found differentially expressed genes methylated regions placentae cord blood samples. Using dimensional reduction analysis, expression methylation variables epigenetically altered classified samples from controls. These were also enriched biological pathways metabolism developmental processes related FGR. Furthermore, three INS, MEG3, ZFP36L2 are implicated imprinting, has been results strongly suggest that highly dysregulated development, abnormal patterns likely alter expression.